三波长肝储备功能检测系统的设计

Insight into the three-wavelength hepatic reserve function detection system

背景:术前评估肝脏储备功能可以让医生得到充分的肝脏信息,从而制定下一步的治疗计划。吲哚青绿排泄试验因为其具有简单、创伤少等优点,被证明是一种有效的预测患者肝储备功能的方法。目的:设计基于吲哚青绿排泄法的便携式肝储备功能测试系统。方法:依据组织对红外光吸收的不同以及脉动选择不同波长LED,选择ARM9平台,设计外围硬件以及探头,并在Window CE系统下设计系统的软件程序,进行整机效果验证。结果与结论:便携式肝储备功能测试系统可以无创、实时的提供吲哚青绿15min滞留率以及血氧饱和度等人体信息,系统采用三波长LED照射手指,并利用光电传感器采集透过手指的光强,软件方面采用数字滤波器及自学习阈值法去除干扰信号。实验证明该系统信号可靠、稳定,效果良好,具有实用性。

BACKGROUND： Preoperative evaluation of hepatic reserve function can offer the message of liver to make the treatment plan early. Indocyanine green excretion test is easy and less-invasive, and has been proved to be an effective method to predict patient’s hepatic reserve function. OBJECTIVE： To design a hepatic reserve function testing system based on indocyanine green excretion test. METHODS： Different wavelength light emitting diode was selected based on human organization’s pulse and absorption of infrared light. The peripheral circuits and probe were designed and the ARM9 platform was selected as the micro-computer in the hardware part; the program was designed in Windows CE in the software part. And the whole system was tested through early experiment. RESULTS AND CONCLUSION： Portable hepatic reserve function testing system could noninvasive and real-time provided the 15 minutes indocyanine green retention rate and blood oxygen saturation. The system used a three-wavelength light emitting diode to light the finger, and used the photoelectric sensor to collect light intensity through the finger. The digital filters and self-learning threshold method were used to remove the interference signal. The experiments show that the system signal is reliable, stable and good effect with practicality.