摘要
探讨一氧化氮 (NO)和一氧化氮合成酶 (NOS)在矽肺发病中的作用和意义。 [方法 ]用生化比色法测定 98例各期矽肺患者血清NO和NOS浓度并与正常对照组比较。 [结果 ]矽肺患者血清NO和NOS高于对照组 (P <0 0 5 ) ,且矽肺期数越高 ,血清NO和NOS浓度越高。矽肺Ⅰ Ⅲ期之间NO和NOS也有差别(P <0 0 5 )。 [结论 ]血清NO和NOS水平上升可能参与矽肺的形成和进展 ,测定NO和NOS的浓度对了解矽肺形成及进展有一定的意义。
Objective] This study is to inquire into function and significance of NO and NOS in silicosis.[Methods] Using colorimetric assay detected NO and NOS levels in serum.98 cases of silicosis were divided into stages Ⅰ、Ⅱ、Ⅲ and 30 normal persons as a control group.[Results] NO and NOS levels in patients of different stage silicosis were more high than those in a control group ( P <0.05).The higher stage was,the higher NO and NOS levels in serum were.[Conclusion] NO and NOS may be related to formation and progress of silicosis,their detection may possess certain useful value to understand the formating and progressing of silicosis.
关键词
矽肺
一氧化氮
一氧化氮合成酶
血清
silicosis
nitric oxide(NO)
nitric oxide synthase(NOS)
