胆囊结石合并胆囊癌患者41例临床分析

Clinical Analysis of 41 Cases of Gallstones Complicated with Gallbladder Cancer

目的应用病例对照的研究方法探讨胆囊癌(GCA)和胆囊结石(GS)的关系。方法对我院2000年1月～2010年12月间收治的胆囊结石合并胆囊癌患者41例(观察组)及未合并胆囊癌的胆囊结石患者41例(对照组)的临床资料进行回顾性分析。结果一般特征分析显示观察组患者的平均年龄显著高于对照组,比较差异有统计学意义(P<0.05)。临床症状比较,观察组患者有较高的胆囊炎、黄疸发病率,胆石症的病史较长,比较差异有统计学意义(P<0.05)。另外,观察组患者的腹痛和体质量下降的发病率也较高,但比较差异无统计学意义(P>0.05)。结论胆囊结石是胆囊癌的致病因素之一,胆囊癌早期诊断困难,晚期治疗效果差。对于高危胆囊结石患者,应引起特别重视,并积极采取预防性的胆囊切除术。

Objective A case-control study was performed to investigate the relationship between gallbladder cancer（GCA） and gallbladder stones （GS）. Methods The 41 patients of combined gallbladder gallstone （Test group） and 41 patients of gallbladder stones without gallbladder （Control group）, that received treatment in my hospital from January 2000 to December 2010, were retrospectively analysis. Results General character analysis showed patients of test group had higher average age （P〈0.05）. As to Clinical symptoms, cases of test group were significantly associated with the history of chronic cholecystitis time, skin stained yellow sclera, and a longer gallstones history （all the p value were smaller than 0.05） . there were no significant difference in intermittent upper abdominal pain and significant weight loss between the two groups. Conclusion Gallstones is one of the most important pathologic conditions of gallbladder carcinoma. The early diagnosis of gallbladder carcinoma is difficult and the therapeutic efficacy is still not satisfactory. Gallstone cancer patients with risk factors should be paid more attention and take active preventive cholecystectomy.