原发性甲状腺弥漫性大B细胞淋巴瘤临床病理观察

Clinical Pathologic Observation:Primary Thyroid Diffuse Large B-cell Lymphoma

目的探讨原发性甲状腺弥漫性大B细胞淋巴瘤的病理诊断与鉴别诊断要点。方法对2例原发性甲状腺弥漫性大B细胞淋巴瘤进行临床病理特点观察,使用LCA、CD20、CD79α、CD3、CD45RO、CEA、TG、TTF-1等免疫组化染色辅助诊断,并文献复习。结果原发性甲状腺弥漫性大B细胞淋巴瘤临床诊断困难,镜下病理形态多样,免疫组化B细胞标记(+)。结论原发性甲状腺弥漫性大B细胞淋巴瘤少见,临床易漏诊且侵袭性较高,因此准确、完整的病理诊断对临床治疗及预后十分重要,免疫组化具有很重要的辅助诊断作用。

Objective To investigate the pathological features and differential diagnosis of primary thyroid diffuse large Beell lymphoma. Methods Examining the clinical and pathological features of two cases of primary thyroid diffuse large B-cell lymphoma, by using the LCA, CD20, CD79~, CD3, CD45RO, CEA, TG, TTF-1 and other immunohistochemical staining to assist diagnosis and literature was reviewed. Results The primary thyroid diffuse large B-cell lymphoma had histological feature as polymorphous, was difficult to be diagnosed by pathologists,and immunohistochemistry B cell markers（＋）. Conclusion The primary thyroid diffuse large B-cell lymphoma, which is highly invasive,is a rare kind of diseases and easily missed in clinical diagnosis and treatment. Thus,an accurate and complete pathological diagnosis is very important for the clinical treatment and prognosis. Iimmunohistoehemistry staining is important in diagnosing the disease.