2240株临床分离菌耐药性分析

Drug Resistance of 2204 Clinical Pathogenic Bacteria

目的了解临床分离病原菌的分布特点及耐药性,为临床合理使用抗生素提供参考。方法用法国生物梅里埃公司生产的VITEK2-compact仪器对我院住院、门诊患者临床标本做菌株鉴定和药物敏感性测定。结果 2012年5～8月间,7 865份临床标本中共分离出病原菌2 240株,其中主要有鲍曼不动杆菌493株,大肠埃希菌356株,肺炎克雷伯菌333株,铜绿假单胞菌304株,阴沟肠杆菌118株。阴沟肠杆菌对丁胺卡那霉素、亚胺培南和头孢吡肟敏感率为100%,大肠埃希菌对厄他培南和亚胺培南敏感率较高分别为94.1%和96.91%。结论临床病原菌的检出率较低,细菌的耐药性日趋严重,临床治疗应依据药敏试验结果合理选用抗菌药物,降低病原菌耐药性,提高治愈率。

Objective To investigate clinical distribution and drug provide reference for rational use of antimicrobial agents in clinic. Methods resistance of pathogenic bacteria, and to The VITEK2-compact instrument was adopted to identify bacteria and test drug sensitivity for clinical specimens from our hospital. Results From May 2012 to August 2012,2 240 strains of pathogens were isolated from 7 865 clinical specimens. The most common isolates were Acinetohaeter haumanii （ 493 ）, Escherichia coli（ 356 ）, Klebsiella pneumoniae （ 333 ）, Pseudomonas aeruginosa（304） and Enterobacter cloacae（ll8）. The sensitive rate of Enterobacter cloacae to amikacin, imipenem and cefepime was 100% respectively. Escherichia coli had high sensitive rate to ertapenem and imipenem with 94.1 and 96.91% respectively. Conclusion The detection rate of pathogenic bacteria is low, and drug resistant strains become a more and more serious problem. Thus,the therapy of infection should he based on the antibiotic sensitivity tests and it is necessary to give an appropriate use of antibiotics in clinic for carrying on the prevention and therapy of infection.