血管性痴呆患者的痴呆程度与血清SCD40L的相关性研究

Study of the Correlation Between the Severity of Dementia and Serum SCD40L of Patients withVascular Dementia

【目的】探讨血管性痴呆（VD）患者血清SCD40L水平变化及与痴呆严重程度的相关性。【方法】采用简明精神状态量表（MMSE）对患者进行智能评定，并对60例VD患者和30例正常对照者进行血清SCD40I，的检测，将SCD40L与MMsE进行相关性分析。【结果】轻、中度VD患者血清sCD40L均明显高于正常对照组（P〈0．01），其中中度痴呆组患者SCD40L水平高于轻度痴呆组患者，二者比较差异具有显著性（P〈0．01）。轻度痴呆组和中度痴呆组患者MMSE量表评分均较低，与正常组比较差异具有显著性（P〈0．01）；其中中度痴呆组患者MMSE量表评分低于轻度痴呆组患者，二者比较差异具有显著性（P〈0．01），且血清SCD40L与MMSE呈负相关。【结论】VD患者血清SCD40L浓度明显升高，其可能参与了VD的发生和发展。

[Objective] To explore the change of serum SCD40L level in patients with vascular dementia and its correlation with the severity of dementia. [Methods]Mini-mental state examination（MMSE ） was used for assessing the intelligence of patients. Serum SCD40L of 60 patients with vascular dementia and 30 normal controls were measured. The correlation between SCD40L and MMSE was analyzed. [Results]Serum SCD40L of patients with mild and moderate vascular dementia was significantly higher than that of normal control group （ P 〈0.01）. Serum SCD40L of moderate dementia patients was higher than that of mild dementia patients, and there was significant difference（ P 〈0.01）. MMSE score of patients with mild and middle dementia was lower, and there was significant difference between mild or middle dementia groups and control group（ P 0.01）. Serum SCD40L was negatively correlated with MMSE. [Conclusion] Serum SCD40L of patients with vascular dementia obviously increases, which may be involved in the occurrence and development of vascular dementia.