干扰素α-1b对扁平疣患者外周血免疫因子的影响及疗效分析

Effect of Hapgen on Immune Factors in Peripheral Blood of Patients with Flat Warts and Effi-cacy Analysis

【目的】观察干扰素a-lb对扁平疣患者血清免疫因子的影响及临床疗效。【方法】选择符合标准的85例扁平疣患者随机分为观察组43例和对照组42例，观察组给予干扰素a-lb联合异维A酸胶丸治疗，对照组单纯给予干扰素a-1b，治疗28d后观察两组患者的临床疗效，以及血清IL-2、IL-10的水平变化。【结果】观察组临床总有效率为83．72％，明显高于对照组的61．90％（P〈0．05）；两组患者血清IL-2水平升高、IL-10水平降低，与本组治疗前比较差异均有统计学意义（P〈0．05），但两组之间比较差异无显著性（P〉0．05）。【结论】干扰素cclb联合异维A酸胶丸治疗扁平疣疗效显著，可能与调节外周血Thl／Th2型细胞因子失衡有关。

[Objective]To observe the effect of hapgen on serum immune factors in patients with flat warts and clinical efficacy. [Methods]Totally 85 cases of flat warts accordance with the standard were randomly di- vided into the observation group（n=43） and control group（n=42）. The observation group was given hapgen combined with isotretinoin, and the control group was given hapgen only. After treatment for 28 days, the clinical effieacy of two groups and the change of serum IL-2 and IL-10 were observed. [Results]The total ef- fective rate of observation group was 83. 72%, which was significantly higher than that of control group （61.90%）（ P d0.05）. Serum IL-2 elevated and serum IL-10 reduced in two groups, and there was significant difference before and after treatment（ P d0.05）, but there was no significant difference between two groups（ P 〉0.05）. [Conclusion]Hapgen combined with isotretinoin for the treatment of flat warts has significant effi- cacy, which may be related to the regulation of Thl/Th2 cytokine imbalanee.