度洛西汀与氟西汀治疗抑郁症的对照研究

Comparative Study of Duloxetine vs Fluoxetine for the Treatment of Depression

【目的】探讨度洛西汀与氟西汀治疗抑郁症的疗效与安全性。【方法】将68例抑郁症患者随机分为度洛西汀组与氟西汀组进行对照研究，疗程8周。采用汉密尔顿抑郁量表（HAMD）和不良反应量表（TESS）在治疗前及治疗1、2、4、8周末评定临床疗效和不良反应。【结果】治疗2周，度洛西汀组HAMD评分较氟西汀组明显下降（P〈0．05），治疗8周，度洛西汀组和氟西汀组的有效率分别为88．2％和85．3％，两组间无显著性差异（P〉0．05）。两组不良反应比较无显著性差异（P〉0．05）。【结果】度洛西汀治疗抑郁症疗效显著，与氟西汀相当，安全性高，且度洛西汀起效更快。

[Objective]To explore the efficacy and safety of duloxetine and fluoxetine for the treatment of depression. [Methods] Sixty-eight patients with depression were randomly divided into duloxetine group（ n = 34） and fluoxetine group（ n =34）. The treatment course was 8 weeks. Hamilton depression scale（HAMD） and treatment emergent symptoms scale（TESS） were used to evaluate the efficacy and side-effect respectively before and after treatment for 1, 2 ,4 and 8 weeks. [Results] Compared with fluoxetine group, HAMD scores in duloxetine group obviously decreased after treatment for 2 weeks（ P d0.05）. The effective rate of duloxe- tine group and fluoxetine group after treatment for 8 weeks were 88.2% and 85.3% respectively, but there was no significant difference（ P 〉0.05）. And there was no significant difference in side effect between two groups. [Conclusion] Duloxetine has a notable efficacy equivalent to fluoxetine and higher safety for the treat- ment of depression, and the former takes effect more rapidly.