摘要
【目的】探讨宫颈病变后患者外周血T淋巴细胞亚群CD3、CD4、CD8的表达水平及意义。【方法】选择慢性宫颈炎+CINI级30例(A组),CINII~HI级30例(B组),宫颈癌30例(C组),用流式细胞仪检测并比较HR_HPV阳性且发生宫颈病变患者外用血T淋巴细胞亚群CD3、CD4、CD8的表达水平。【结果】A组、B组、C组的CD3、CD4水平依次呈下降趋势,而CD8逐渐上升;C组的CD4/CD8比值显著低于A组、B组,并出现倒置现象。A组与B组cD3略下降,但差异无显著性(P〉0.05),余各组间cD3、CD4、CD8、CD4/CD8淋巴细胞的比较均具有差异性(P〈O.05)。【结论】随着宫颈病变程度的加重,机体细胞免疫逐渐发生免疫功能低下,甚至出现免疫抑制状态。
[Objectivel To explore the expression of peripheral blood T- lymphocyte subsets CD3, CD4 and CD8 in patients with cervical lesion and its significance. [Methods] Thirty patients with chronic cervicitis and CINI (group A), 30 patients with CINII - HI (group B) and 30 patients with cervical cancer(group C) were chosen. Flow cytometry was used to detect and compare the expression of peripheral blood T lymphocyte subsets CD3, CD4 and CD8 in patients with cervical lesion and HR-HPV positive. [ResuhsIFI;om group A, group B to group C, the level of CD3 and CD4 declined by turns, while CD8 raised gradually. CD4/CD8 ratio in group C was signifi- cantly lower than that in group A and group B, and the inversion was observed. CD3 in group A and group B slightly decreased, but there was no significant difference( P 〉0.05). There were significant differences in CD3, CD4, CD8 and CD4/CD8 lymphocytes among groups( P d0.05). [ConelusionlWith the increasing of the degree of cervical lesion, low immune function of body immune cells occurs gradually, and even immunosuppression state ap- pears.
出处
《医学临床研究》
CAS
2013年第2期265-266,共2页
Journal of Clinical Research
关键词
宫颈疾病
免疫学
乳头状瘤病毒感染
uterine cervical diseases/IM
papilIomavirus infections