血液透析患者骨密度与脂联素的关系

Relationship between bone mineral density and serum adiponect in patients on maintenance hemodialysis

目的:探讨血液透析患者骨密度与脂联素的关系以及其在骨质疏松症发病中的作用。方法:用DEXA骨密度仪测定40例血液透析患者以及15名非血液透析患者为对照组的腰椎及股骨端骨密度,并检测脂联素。结果:与对照组比较,血液透析患者的腰椎及股骨端各部位骨密度明显下降,差异有统计学意义(P<0.01);观察组脂联素明显低于对照组,差异有统计学意义(P<0.01)。结论:血液透析患者骨质疏松患病率高,更容易发生骨折,脂联素参与了血液透析患者骨质疏松的发病。

Objective： To investigate the relationship between bone mineral bone density（BMD）and adiponectin（ADPN）in patients on maintenance hemodialysis （MHD）and its mechanism. Methods： Dual energy X-ray absorptiometry was used to measure BMD of the lumbar spine and the proximal femur in 40 patients on MHD and 15 patients without dialysis as the control groups.Serum adiponectin were determined.Results： BMD of the lumbar and the proximal femur in patients in MHD descended significantly （P〈0.01）.Serum adiponectin was higher in test group than those in control group significantly （P〈0.01）.Conclusion： The adiponectin has a close relation with osteoporosis,the level of adlponectin was likely to play an important role in patients on MHD.