地中海贫血筛查指标的分析评价

Analysis and Evaluation on Indicators of Thalassemia Screening

目的评价红细胞检测中各个参数在产前筛查地中海贫血中的价值。方法分别对确诊地贫的50例孕妇及同期非地贫的1053例孕妇的红细胞参数(MCV、MCH、RDW-CV、RDW-SD)进行比较,并作统计学分析。结果地贫孕妇和正常孕妇间MCV、MCH、RDW-CV、RDW-SD均有统计学差异。其中MCV、MCH、RDW-CV、RDW-SD灵敏度分别为93%、75%、71%、73%,特异度分别为81%、92%、66%、75%。MCV与RDW-SD平行联合判断灵敏度为61%,特异度为98%,系列联合判断灵敏度为94%,特异度为77%。结论 MCV灵敏度最高,平行联合判断可提高灵敏度,系列联合判断可提高特异度。

Objective To evaluate the value of parameters of RBC detection in the antenatal thalassemia screening.Methods Total 50 pregnant women with thalassemia and 1053 normal controls were enrolled in this study and received routine hematological testing.The levels of MCV,MCH,RDW-CV and RDW-SD were compared between the two groups.Results There were significant differences in MCV,MCH,RDW-CV and RDW-SD between the two groups.The sensitivity of MCV,MCH,RDW-CV and RDW-SD were 93%,75%,71% and 73%,respectively;and the specificity were 81%,92%,66% and 75%.The sensitivity and specificity of parallel combined test of MCV with RDW-SD were 61% and 98%.The sensitivity and specificity of serial combined test of MCV with RDW-SD were 94% and 77%.Conclusion MCV is with a highest sensitivity.Parallel combined test of MCV and RDW-SD can increase the sensitivity,and serial combined test can heighten the specificity in the diagnosis of thalassemia.