地佐辛在预防全麻苏醒期躁动的临床效果观察

Clinical Effect of Dezocine in Prevention of Restlessness during Anesthesia

目的观察地佐辛在预防全麻苏醒期躁动的临床效果。方法选择全麻腹腔镜宫外孕手术50例,年龄在25～38岁之间,将其随机分为两组,对照组(A组)和地佐辛组(B组),每组各25例。两组均采用静吸复合麻醉,手术结束前15 min给予A组上臂三角肌肌注生理盐水2 ml,B组肌注地佐辛0.1 mg/kg。观察每组患者拔管后5 min的疼痛及躁动评分;从停药到患者清醒的时间;拔管后是否发生呼吸抑制、恶心呕吐、头晕、皮肤瘙痒等相关不良反应。结果 B组患者术后躁动率明显低于A组(P<0.05);B组在镇痛评分显著低于A组(P<0.05)。两组在呼吸抑制、便秘、瘙痒等不良反应差异无统计学意义。结论手术结束前15 min肌注地佐辛镇痛可减少全麻苏醒期的躁动,且术后不良发生率低。

Objective Observation of clinical effect of dezocine in prevention of restlessness during anesthesia.Methods General anesthesia laparoscopy for ectopic pregnancy operation in 50 patients,aged 25-38 years old,were randomly divided into two groups,control group（group A） and dezocine group（group B）,25 cases in each group.Two groups were treated by combined intravenous anesthesia,operation end 15 min prior to A group of upper arm deltoid intramuscular injection of saline 2 ml,group B intramuscular injection of dezocine 0.1 mg/kg.Each group of extubation in patients after 5 min pain and agitation scale;from the withdrawal to patients awake time;respiratory depression,nausea and vomiting,dizziness,skin itching and other related adverse reaction after extubation were observed.Results In group B,patients emergence agitation rate was significantly lower than that in group A（P0.05）;pain scores in group B were lower than those in group A（P0.05）.Respiratory depression,constipation,itching and other adverse reactions between the 2 groups had no significant difference.Conclusion Restlessness during the recovery period after general anesthesia can be reduced by injection dezocine analgesia 15 min before the end of the operation,which had low incidence of emergence agitation.