甲泼尼龙辅治大叶性肺炎支原体肺炎疗效分析

Methylprednisolone in the Assistance Treatment of Lobar Pneumoniae Mycoplasma Pneumoniae in Children

目的观察小剂量甲泼尼龙辅助治疗小儿以大叶受累的肺炎支原体肺炎(MPP)的临床疗效。方法将48例胸部X线片表现为大叶受累的MPP患儿随机分为对照组和治疗组,两组均给予常规治疗,治疗组在此基础上给予小剂量甲泼尼龙1～2 mg/(kg.d),3～5 d,比较两组退热、胸片大片阴影消退时间、住院时间及不良反应。结果治疗组发热持续时间、胸片大片影消退时间及住院时间明显少于对照组(P<0.05)。两组患儿均未发生严重不良反应。结论小剂量甲泼尼龙辅助治疗大叶受累的MPP,可有效的缓解临床症状,缩短发热和胸部大片影消退时间,从而减少住院天数,并且不良反应少,值得临床推广应用。

Objective To explore the clinical effect of methylprednisolone in adjunctive therapy of lober mycoplasma pneumoniae pneumonia（MPP）.Methods Forty-eight cases of mycoplasmal pneumonia were divided into two groups according to chest X-rays manifested of lobal pneumonia.Twenty-four cases in control group were given routine treatment and twenty-four cases in observation group were added the low dose methylprednisolone intravenously for 3-5 days.Temperature recovery time,hospital stay time,chest X-rays and adverse reactions were compared between 2 groups.Results There were significant differences between the two groups in duration of fever,regression of lobar shadow and hospital time（P0.05）.Conclusion Adjunctive therapy with low doses of methylprednisolone in treating mycoplasmal lobar pneumonia could effectively relieve the clinical symptoms,decrease the duration of fever and restore of lobar shadow,reduce the hospital time and fewer adverse reactions,which was worthy of clinical use.