摘要
目的研究小鼠雾化吸入羟喜树碱后原形药物经尿液、粪便的排泄。方法小鼠经雾化给药后,分别收集给药前及给药后0～3,～6,～9,～12,～24,～48 h的尿液和粪便样品,采用高效液相色谱法检测尿液和粪便中的原形药和代谢产物。结果原形药物主要从粪便中排出,粪便中原形药物在12 h内排泄速度很快,之后趋于平稳。尿液中前3 h羟喜树碱的排泄量最大,药物在肾脏不易蓄积。结论雾化吸入羟喜树碱后原形药物的代谢可能为其主要消除方式。
Objective To study the excretion of hydroxycamptothecine （HCPT） in urine and feces of mice via aerosol administration. Methods The urine and feces samples were collected at baseline and 0-3, 3-6, 6-9, 9-12, 12-24 and 24-48 h after aerosol administration. HPLC-FLD was used to determine the concentration of unchanged HCPT and its metabolites in the urine and feces. Results The unchanged drug was mainly excreted in the feces, with most of the drug excreted within the first 12 h. Excretion of HCPT in the urine largely occurred in the first 3 h without renal accumulation. Conclusion Hydroxycamptothecine is mainly excreted unchanged after aerosol administration in mice.
出处
《医药导报》
CAS
北大核心
2013年第3期297-300,共4页
Herald of Medicine
关键词
羟喜树碱
雾化
代谢
色谱法
高效液相
Hydroxycamptothecine
Aerosol inhalation
Metabolism
High performance liquid chromatography
