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乙酰基阿托品盐酸盐的制备 被引量：3

Preparation of Acetyl Atropine Hydrochloride
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摘要 乙酰基阿托品盐酸盐是合成硫酸阿托品的关键中间体,文章通过采用SO2Cl2-DMF组成的Vilsmeier-Haack型复合物作为脱水剂,以当量的乙酰托品酸和托品醇盐酸盐为原料,在室温下进行酯化反应制备乙酰基阿托品盐酸盐,收率接近定量。 Acetyl atropine hydrochloride is a key intermediates for the synthesis of atropine sulfate. N,N-dimethylchlorosulfitemethaniminium chloride （SO2CI2-DMF） was used in the synthesis of acety latropine hydrochloride via esterification between equimolar amounts of acetyl tropic acid and tropine hydrochloride under mild conditions with quantitative yield.
作者 王龙书 黄建军 罗春 肖乐扩
机构地区 广州白云山汉方现代药业有限公司
出处 《广东化工》 CAS 2013年第6期46-46,共1页 Guangdong Chemical Industry
关键词 Vilsmeier-Haack型复合物(SO2Cl2-DMF) 乙酰阿托品盐酸盐 酯化反应 中间体 N,N-dimethylchlorosulfltemethaniminiumchloride（SO2Cl2-DMF）： acetylatropinehydrochloride： esterificationreaction： intermediate
分类号 TQ464.7 [化学工程—制药化工]
  • 相关文献

参考文献5

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共引文献10

同被引文献26

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引证文献3

二级引证文献3

广东化工
2013年 第6期

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