期刊文献+

3-环丙基-3-氧代丙酸甲酯的合成工艺改进

Improved Synthesis of 3-Cyclopropyl-3-oxopropionic Acid Methyl Ester
下载PDF
导出
摘要 本研究以环丙甲酮、碳酸二甲酯为原料在氢化钠的存在下合成了3-环丙基-3-氧代丙酸甲酯,改进后的工艺反应周期短,成本低廉,收率达到86.5%,适合于工业化生产。 3-Cyclopropyl-3-oxopropionic acid methyl ester was prepared from Cyclopropyl methyl ketone and dimethyl carbonate in the presence of sodium hydride. The method was improved for industrial production and the product was obtained in 86.5 % yield.
作者 徐斌 程锦涛
出处 《广东化工》 CAS 2013年第6期50-51,共2页 Guangdong Chemical Industry
关键词 3-环丙基-3-氧代丙酸甲酯 合成 工艺改进 J3-Cyclopropyl-3-oxopropionic acid methyl estcr synthesis: process improvement
  • 相关文献

参考文献8

  • 1蔡正艳,周伟澄.匹伐他汀钙的合成[J].中国医药工业杂志,2007,38(3):177-180. 被引量:9
  • 2Aoki T, Nishimura H, Nakagawa S, et al. Pharmacologicalprolile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase[J]. Arzneim-ForschDrugRes, 1997, 47.- 904-909.
  • 3Teng Xin , Keys Heather , Jeevanandam Arumugasamy , et al. Structure-activity relationship study of [l,2,3]thiadiazolenecroptosis inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2007, 17(24): 6836-6840.
  • 4Umetani Kunihisa, Shimaoka Takashi, Yamaguchi Minoru, et al. 4- cyclopropyl-l,2,3-thiadiazole compound, agrohorticultural plant disease controlling agent and method of using the same[P]. EP, 1852428, 2007.
  • 5Walker Joel R, Rothman Steven C, Poulter C Dale. Synthesis and Evaluation of Substrate Analogues as Mechanism-Basedlnhibitors of Type 1I lsopentenyl Diphosphate lsomerase[J]. Journal of Organic Chemistry; 2008, 72(2): 726-729.
  • 6Qin Jun, Rao Ashwin, Chen Xiao, et al. Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia[J]. Medicinal Chemistryletters, 2011, 2(2): 171-176.
  • 7Satyanarayana Reddy manne, Eswaraiah Sajja, Sahadeva Reddy, et al . Improved process for the preparation of highly pure (3tL5S)-7-[2-cyclopropyl-4-(fluorophenyl)quinolin-3-yl]-3 5-dihydroxy-6(E)-heptenoic acid and pharmaceutically acceptable salts thereof[P]. WO2010089770.
  • 8Wu D, Fu X, Li J, et al. Methoxycarloonylation ofketones with dimethyl carbonate over solid base[J]. Catalysis Communication, 2008, 9(5): 680-684.

二级参考文献6

  • 1Aoki T,Nishimura H,Nakagawa S,et al.Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase[J].Arzneim-Forsch DrugRes,1997,47:904-909.
  • 2Miyachi N,Yanagawa Y,lwasaki H,et al.A novel synthetic method of HMG-CoA reductase inhibitor NK-104 via a hydroboration-cross coupling sequence[J].Tetrahedron Left,1993,34(51):8267-8270.
  • 3Fujikawa Y,Suzuki M,Iwasaki H,et al.Quinoline type mevalonolactones:EP,304063[P].1989-02-22.(CA 1989,111:134010)
  • 4Wess G,Kesseler K,Baader E,et al.stereoselective synthesis of HR 780 a new highly potent HMG-CoA reductase inhibitor[J].Tetrahrdron Lett,1990,31(18):2545-2548.
  • 5Hyama T,Minami T,Yanagawa E,et al.Preparation of pyridine-type mevalonolactone intermediates:JP,53 10700[P].1993-11-22.(CA 1994,120:244704)
  • 6Roth BD.(R-(R^*R^*))-2-(4-Fluorophenyl)-beta,deltadihydroxy-5-(1-methylethyl-3-phenyl-4((phenylamino)-carbonyl)-1H-pyrolle-1-heptanoic acid,its lactone form andsalts thereof:EP,409281[P].1991-01-23.(CA 1991,115:29107)

共引文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部