骨髓小粒在再生障碍性贫血和低增生骨髓增生异常综合征诊断和鉴别诊断中的意义

The significance of examination of marrow parvule in diagnosis and differential diagnosis in aregenerative anemia and hypomyeloplastic MDS

目的探讨骨髓小粒在再生障碍性贫血(AA)和低增生骨髓增生异常综合征(MDS)的诊断和鉴别诊断中的意义。方法对已明确诊断的30例AA和6例低增生MDS的骨髓小粒进行回顾性分析。结果 AA组的骨髓小粒中非造血细胞比率显著高于低增生MDS组(P<0.01),后者的原粒+早幼粒细胞比率高于前者(P<0.05),并有病态造血。结论骨髓小粒分析对AA和低增生MDS的诊断与鉴别诊断有重要的参考价值。

Objective To explore the significance of examination of marrow parvules in diagnosis and differential diagnosis between are- generative anemia （AA） and myelodysplastic syndrome （MDS） with hypoplasia. Methods The data of examination of marrow parvules in 30 ca- ses of AA and 6 cases of MDS with hypoplasia were retrospectively analyzed. Results The proportion of non - hematopoietic cells in marrow par- yules of AA group was obviously higher than that of hypomyeloplastic MDS group （ P 〈0.01 ）. The proportion of myeloblasts and pmmyelocytes in the latter was obviously higher than that of the former （ P 〈 0.05 ）, moreover, dyshematopoiesis was appeared in the latter. Conclusion The anal- ysis of marrow parvules has important reference value in diagnosis and differential diagnosis between AA and hypomyeloplastic MDS.