滋阴清热法治疗咳嗽变异性哮喘随机对照研究

Therapeutic Effect of Nourishing Yin and Clearing Heat Method on Patients with Cough Variant Asthma

目的:观察滋阴清热法治疗咳嗽变异性哮喘的临床疗效。方法:将84例咳嗽变异性哮喘患者,随机分为2组,治疗组予滋阴清热方(黄芩、麦冬、知母、沙参等,1剂,早晚分服);对照组予茶碱缓释胶囊(100 mg/次,日2次),4周为1疗程。观察2组的临床疗效、咳嗽缓解和消失时间及治疗前后外周血IFN-γ、IL-4水平。结果:治疗组总有效率95.24%,明显高于对照组(78.57%),2组比较,有统计学意义(P<0.05);治疗组治疗后IFN-γ和IL-4因子较治疗前明显改善(P<0.01);治疗组治疗后IFN-γ和IL-4和对照组治疗后比较,有统计学意义(P<0.01或0.05);治疗组咳嗽缓解和消失时间较对照组明显改善,2组比较,有统计学意义(P<0.01)。结论:滋阴清热法治疗咳嗽变异性哮喘疗效较好,值得临床推广应用。

Objective：To study the therapeutic effect of nourishing yin and clearing heat method on patients with cough variant asthma（CVA）. Methods： 84 patients with CVA in our department were divided into two groups randomly. Patients in the group A were treated with nourishing yin and clearing heat method, the group B were treated with theophylline sustained- release capsules only. The clinical effect, the IFN-y and IL-4 levels, the time of cough relief and disappearance of the two groups were compared. Results： The excellent rate of the group A was 95.24%, which was significantly higher than the group B 78.57 % （ P 〈 0.05） ; the level of 1FN-y or IL-4 level in group A was significantly different before and after treat- ment, which was also significantly between the two groups after the treatment（ P 〈 0.01 or 0.05） ;the time of cough relief and disappearance were significantly different between the two groups （P 〈 0.01 ）. Conclusion： Nourishing yin and clearing heat method is a safe and efficient treatment method of patients with CVA, it is worthy of clinical implication.