诺更宁在绝经后妇女冠心病中的防治作用

Preventive and curative effects of kliogest on coronary heart disease of post menopause women

目的 探讨诺更宁在绝经后妇女 (PMW)冠心病 (CHD)中的防治作用。方法 绝经后女性冠心病 6 0例随机分为诺更宁治疗组和常规治疗对照组。两组均在治疗前、治疗后 6个月及 12个月测血脂。同时观察两组在 12个月内的心性事件发生率。结果 治疗6个月及 12个月后 ,治疗组胆固醇 (TC)、低密度脂蛋白胆固醇 (L DL-C)明显降低 ,高密度脂蛋白胆固醇 (HDL -C)明显升高。治疗 12个月时治疗组 HDL-C显著高于对照组 (P<0 .0 5 ) ;LDH-C显著低于对照组 (P<0 .0 5 ) ;治疗后甘油三酯 (TG)水平较治疗前及对照组稍有升高 ,但无显著性差异 (P>0 .0 5 )。治疗 12个月治疗组总心性事件发生率 (10 % )明显低于对照组 (43% ) (P<0 .0 1)。结论 诺更宁可显著改善 PMW之 CHD的血脂紊乱状况 ,使心性事件的发生率明显降低。

Objective To investigate the preventive and treatment effect of kliogest on coronary heart disease (CHD) of post menopause women(PMW).Methods 60 cases of CHD of PMW were divided into two groups:kliogest treatment group and control group.For both groups,blood lipids were tested before treatment and 6 and 12 months after treatment.Meanwhile,their incident rates of cardiac events during 12 months were observed.Results After 6 and 12 months' treatment with kliogest,the patients' cholesterol (TC) and lipoprotein cholesterol of low density (LDL-C) was decreased and their lipoprotein cholesterol of high density (HDL-C) was increased.After 12 months,HDL-C was higher(P<0.05) and LDL-C was lower(P<0.05) in the treatment group than in the control group.TG level was slightly higher but with no significant difference (P>0.05).The incident rate of total cardiac-events in the treatment group (10%) was remarkably lower than that in the control group (43%) (P<0.01).Conclusion Kliogest can significantly improve the confused condition of blood lipids on CHD of PMW with lower incident rate of cardiac events.