老年男性与泌尿生殖系有关的多原发恶性肿瘤24例分析

An analysis on aging male with multiple primary malignant neoplasms in genitourinary organs of 24 cases

目的 探讨老年男性与泌尿生殖系有关的多原发恶性肿瘤的临床意义。 方法 1972年 1月至 1999年 12月收治与泌尿生殖系有关的多原发恶性肿瘤男性患者 41例 ,其中老年患者 2 4例 ,对其进行回顾性分析。 结果 与泌尿生殖系有关的多原发恶性肿瘤患者占同期泌尿生殖系恶性肿瘤患者的 4 8% ,其中老年患者占 5 8 5 %。 2 4例老年患者平均患病年龄为 73岁 ,第一癌与第二癌平均间隔为 2 3年。泌尿生殖系统与消化系统最为常见 ,第一癌前者占 75 % ,后者占 17% ;第二癌前者占 46 % ,后者占 2 9%。 2 3例获得随访 ,随访中位时间 3 5年 ,14例死亡 ,直接死因为第二癌者 12例。 结论 多原发恶性肿瘤在泌尿外科并不少见 ,应重视对第二癌的诊疗 ,这对老年人生活质量的改善有重要意义。

Objective To investigate clinical significance of multiple primary malignant neoplasms of genitourinary organs in the aged. Methods From January 1972 to December 1999, 41 patients with multiple primary malignant neoplasms were treated in our department and analysed retrospectively. Among them 24 were aged men. Results The percentage of multiple primary neoplasms was 4 8% in all the genitourinary malignant neoplasms investigated, including 24 aged male patients with average age of 73 years. The average interval between the onset of the first and second primary lesions was 2 3 years. The genitourinary and digestive organs were commonly involved. Twenty three cases were followed up for a median of 3 5 years. Out of the 14 died patients, 12 died directly of the onset of the second neoplasm. Conclusions Multiple primary neoplasms in urology were not rare and more attention should be paid to the diagnosis and treatments of the second neoplasms, it is important for improving the life quality of the aged patients.