持续皮下胰岛素输注治疗初诊2型糖尿病50例观察

Continuous Subcutaneous Insulin Infusion Treatment in Newly Diagnosed Type 2 Diabetes:Observation of 50 Cases

目的对持续皮下胰岛素输注治疗初诊2型糖尿病临床疗效进行统计和分析。方法选取我院2011年2月至2012年8月收治的初发2型糖尿病患者50例,对患者采用胰岛素泵进行持续性的胰岛素皮下输注(CSII)方法治疗,为治疗组;同时选取50例初发2型糖尿病患者,采用多次皮下注射胰岛素(MSII)方法治疗,为对照组,对比两组患者在治疗两周后空腹血糖(FBG)、餐后2h血糖(PBG)变化、胰岛素的使用总量,血糖达到生理性指标的时间及合并症低血糖的发生率。结果治疗后两组患者FBG及PBG均明显降低,差异有统计学意义(P<0.001),但两组间比较差异无统计学意义(P>0.05);CSII组胰岛素的使用量较MSII组明显减少(P<0.05),血糖达标时间明显缩短(P<0.05),合并症低血糖的发生率显著减少(P<0.05)。结论采用持续性的胰岛素输注方法治疗初发2型糖尿病,能有效改善患者的空腹、餐后血糖指标,降低胰岛素的使用总量,明显缩短用药后血糖达到正常水平的时间,低血糖发生率较低,适宜临床上广泛应用于治疗初诊的2型糖尿病。

Objective To continuous subcutaneous insulin infusion treatment in newly diagnosed type 2 diabetes mellitus clinical statistics and analysis.Methods From February to 2012 in our hospital in 2011 August treated patients with newly diagnosed type 2 diabetic patients 50 cases,using insulin pump continuous subcutaneous insulin infusion（CSII） treatment methods,treatment groups;at the same time selecting 50 patients with type 2 diabetes mellitus patients,multiple subcutaneous insulin injection（MSII） method of treatment,as compared to the control group,compared the two groups of patients in treatment for two weeks after fasting blood glucose（FBG）,2 hour postprandial blood glucose（PBG）,the total amount of use of changes in insulin,glucose reaches physiological indicators of time and complication incidence of hypoglycemia.Results After treatment,two patients of FBG and PBG were decreased,the difference was statistically significant（P0.001）,but the difference between the two groups was not statistically significant（P0.05）;group CSII insulin usage than in MSII group decreased significantly（P0.05）,blood glucose standard time was significantly shortened（P0.05）,comorbidity hypoglycemia incidence rate decreased significantly（P0.05）.Conclusion The use of continuous insulin infusion treatment in newly diagnosed type 2 diabetic patients,can effectively improve the fasting,postprandial glycemic index,reduced insulin use gross,shortened significantly after administration of glucose to normal levels at the time,a low incidence hypoglycaemia,suitable for wide clinical application in the treatment of newly diagnosed type 2 diabetes mellitus.