缬沙坦联合氨氯地平治疗原发性高血压的疗效观察

Efficacy of valsartan combined amlodipine treatment of essential hypertension

目的探讨缬沙坦联合氨氯地平治疗原发性高血压的治疗效果。方法选择90例原发性高血压患者采用随机数字表法将患者随机分为缬沙坦组(A组)和氨氯地平组(B组)及联合组(缬沙坦联合氨氯地平治疗)(C组),每组各30例。比较三组患者的临床治疗效果及用药安全性。结果治疗4周后,C组的总有效率达96.7%%,明显高于A组和B组的总有效率,差异有统计学意义(P<0.05)。C组的显效率达76.7%,也明显高于A组和B组的显效率,但三组间的有效率比较差异不显著(P>0.05)。C组的不良反应发生率明显低于A组和B组,差异有统计学意义(P<0.05),但A组、B组间的不良反应发生率比较差异不显著(P>0.05)。结论缬沙坦联合氨氯地平治疗原发性高血压疗效确切,无明显不良反应,值得推广和应用。

Objective To explore the effect of valsartan amlodipine treatment of essential hypertension. Methods 90 patients with essential hypertension patients used a random number table were randomly divided into valsartan group （A） and amlodipine group （B） and the combination group （valsartan amlodipine treatment）（C group）,30 in each group, the clinical effect and safety of drugs were compared in three groups. Results After treatment 4 weeks, the total effective rate of C group was 96.7%,was significantly higher than the group A and group B, the difference was statis- tically significant （P 〈 0.05）. The markedly effective rate of Group C was 76.7% ,was significantly higher than the group A and group B,but difference was not significant （P 〉 0.05） among the three groups, the incidence of adverse events of Group C was significantly lower than group A and group B, the difference was statistically significant （P 〈 0.05） ,but the difference of incidence of adverse reactions between the A and B group was not significant （P 〉 0.05）. Conclusion The efficacy of valsartan combined amlodipine treatment essential hypertension, no significant adverse reactions,worthy of promotion and application.