血清降钙素原、C反应蛋白、白细胞计数对细菌性感染的诊断价值研究

Serum procalcitonin and C-reactive protein, white blood cell count diagnostic value of bacterial infection

目的探讨血清降钙素原、C反应蛋白、白细胞计数对细菌性感染的诊断价值，为在细菌性感染的诊断、鉴别诊断及指导临床应用抗生素提供指导依据。方法本研究共收集2008年2月～2012年5月期间我院收治的46例细菌性感染性疾病。48例非细菌感染性疾病及40名健康体检者作为本组研究对象，分别检测各组的血清降钙素原、C反应蛋白、白细胞计数水平及比较各组的阳性率。结果细菌性感染组PCT、CRP、WBC计数均明显高于非细菌性感染组、健康对照组，差异有统计学意义（P〈0．05）。细菌性感染组PCT阳性率达95．7％，明显高于非细菌性感染组PCT阳性率（12．5％），差异有极其显著性（P〈0．01）。细菌性感染组CRP阳性率达100．0％，高于非细菌性感染组PCT阳性率（87．5％），但差异并不存在显著性（P〉0．05）。细菌性感染组WBC阳性率达93．5％，明显高于非细菌性感染组WBC阳性率（4．2％），差异有极其显著性（P〈0．01）。结论细菌性感染患者的血清降钙素原、C反应蛋白、白细胞计数均明显高于非细菌感染性疾病患者，对细菌性感染患者进行血清降钙素原、C反应蛋白、白细胞计数检测，可以为临床进行早期准确诊断，尽早进行有效合理治疗，取得良好的预后提供有利的参考依据。

Objective To investigate the serum procalcitonin and C-reactive protein, white blood cell count to provide guidance based on diagnostic value in the diagnosis of bacterial infection, differential diagnosis and guide clinical use of antibiotics for bacterial infections. Methods In this study were collected from February 2008 to May 2012 during our hospital 46 cases of bacterial infectious diseases, 48 cases of non-bacterial infectious diseases, and 40 healthy persons as the study, respectively, were detected by group of serum procalcitonin, C-reactive protein, white blood （：ell count level and compare the positive rate of each group. Results Bacterial infection group PCT, CRP, WBC count was significantly higher than the non-bacterial infection group and the healthy control group, the difference was statistically significant（P 〈 0.05）. Bacterial infection group PCT positive rate of 95.7%, was significantly higher than the non-bac- terial infection group PCT positive rate （12.5%）, the difference was extremely significant （P 〈 0.01 ）. Bacterial infec- tion group, CRP positive rate of 100.0%, higher than the non-bacterial infection group PCT positive rate （87.5%）, but the difference was not statistically significant （P 〉 0.05）. Bacterial infection group WBC positive rate was 93.5%, was significantly higher than non-bacterial infection group WBC-positive rate（4.2%）, the difference was extremely significant （P 〈 0.01 ）. Conclusion Bacterial infection in patients with serum procalcitonin, C-reactive protein, white blood cell count was significantly higher than the non-bacterial infectious disease, bacterial infection of bacterial infection in patients with serum procalcitonin and C-reactive protein, white blood cell count testing, clinical early and accurate diagnosis, effective and reasonable treatment as soon as possible to obtain a good prognosis and provide a favorable reference.