普萘洛尔治疗婴幼儿颌面部血管瘤60例临床观察

Clinical observation of propranolol treatment for infantile maxillofacial hemangioma on 60 patients

目的通过临床观察评价普萘洛尔治疗婴幼儿颌面部血管瘤的疗效及风险性。方法收集2010年7月～2012年7月山西省人民医院口腔颌面外科收治的婴幼儿颌面部血管瘤60例,将其随机分为治疗组和临床观察组,各30例,通过门诊随访观察,比较两组颌面部血管瘤大小及颜色变化,同时检测治疗组服用普萘洛尔前后患儿的心率、血压、血糖、肝肾功能变化。结果经过近6个月的走访临床观察,治疗组中较好21例,效果一般9例,无效0例,观察组中效果较好1例,效果一般6例,无疗效23例,同时观察到治疗组中患儿治疗前后1 h的心率有一定变化,其余血压、血糖、肝肾功能变化等指标无明显变化,通过统计学分析,差异无明显统计学意义。结论普萘洛尔治疗婴幼儿颌面部血管瘤疗效肯定,不良反应少,安全性较高。

Objective To observe the clinical efficacy and risk of propranolol therapy use for infantile maxilIofacial hemangiom. Methods Sixty infant maxillofacial vasculartumor patients with hemangiomas that treated in Shanxi Province People＇s Hospital Oral and Maxillofacial Surgery were collected from July 2010 to July 2012. They were randomly divided into treatment group and observation group, each of 30 cases. According to the outpatient follow-up observation, we compared the changes of maxillofacial hemangioma size and color and detected heart rate, blood pressure, blood sugar, changes in liver and kidney function in treatment group before and after administration of propranolol using. Results After nearly six months of visiting to clinical observation, the treatment group was better for the 21 cases, the general effect of the nine cases, seven cases valid observation group, no significant effect of the 23 cases, while observing the treatment of children in the treatment group before and after a certain change in the heart rate of one hour, no significant changes in the rest of the blood pressure, blood sugar, liver and kidney function change indicators, through statistical analysis, had no significant difference. Conclusion Propranolol treatment of infants maxillo- facial hemangioma effective, fewer adverse reactions, higher security.