血清氧化型低密度脂蛋白及其自身抗体与冠状动脉痉挛的关系及调脂治疗对其影响

The correlation of oxidized low-density lipoprotein and its autoantibody with coronary artery spasm and the effect of lipid lowering therapy

目的探讨氧化型低密度脂蛋白(OX-LDL)及其自身抗体与冠状动脉痉挛(CAS)的关系以及调脂治疗对其影响。方法收集2010年6月～2012年6月我院心内科收治的CAS患者46例,另取非CAS患者40例作为对照,给予阿托伐他汀降脂治疗。ELISA法检测OX-LDL及其自身抗体的表达。结果 CAS患者OX-LDL及其自身抗体的表达分别为(32.61±6.08)和(52.36±7.51)μg/mL,显著高于对照组的(21.23±3.47)和(38.44±5.62)μg/ml(t=7.46,P<0.01;t=8.52,P<0.01)。CAS患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、OX-LDL及其自身抗体的表达水平在降脂治疗后均较治疗前显著减低(P<0.05),而高密度脂蛋白(HDL-C)的表达水平治疗后较治疗前显著升高(P<0.05)。结论 CAS患者OX-LDL及其自身抗体的表达显著升高,降脂治疗可以显著降低其表达,有助于减少CAS的发生。

Objective To investigate the correlation between oxidized low-density lipoprotein （OX-LDL） and its autoantibody with coronary artery spasm （CAS） and analysis of the effect of lipid lowering therapy. Methods A total of 46 patients with CAS were enrolled in this study. Another 40 cases of non-CAS person was collected as a control. The CAS patients were treated by atorvastatin. The levels of serum OX-LDL and its autoantibody was measured by ELISA assay. Results The expression of OX-LDL and its autoantibody were （32.61±6.08） and （52.36±7.51） μg/mL, which was significantly higher than that of （21.23±3.47） and （38.44±5.62） μg/mL in control group（t = 7.46, P 〈 0.01; t = 8.52, P 〈0.01）, Compared with pretreatment, the expression of TC, TG, LDL-C, OX-LDL and its autoantibody were significantly decreased at posttreatment （P 〈 0.05）. However, the expression of HDL-C was significantly increased at posttreatment （P 〈 0.05）. Conclusion The high expression of OX-LDL and its autoantibody were found in CAS patients. The lipid lowering therapy can effectively reduce serum levels of OX-LDL and its autoantibody, and which was contributed to decrease CAS.