α-硫辛酸联合神经妥乐平治疗糖尿病周围神经病变的临床观察

Clinical research of α-lipoic acid combined with Neurotropin in treating diabeitc peripheral neuropathy

目的探讨α-硫辛酸联合神经妥乐平治疗糖尿病周围神经病变临床疗效。方法随机将糖尿病周围神经病变患者160例分为观察组和对照组,并分别给予α-硫辛酸联合神经妥乐平和神经妥乐平治疗,疗程2周,对两组患者治疗前后症状和神经传导速度(NCV)测定进行比较。结果正中神经、腓总神经、胫神经的MCV和SCV均显著高于治疗前(P<0.05),且观察组在治疗后MCV和SCV传导速度均好于对照组(P<0.05),观察组有效34例,基本有效43例,无效4例,总有效率达96.25%,显著高于对照组66.25%(P<0.01)。结论α-硫辛酸联合神经妥乐平治疗糖尿病周围神经病变,提高神经传导速度,疗效显著,且无明显不良反应,值得临床推广。

Objective To investigate the clinical value of α-lipoic acid combined with Neurotropin in treating diabeitc peripheral neuropathy. Methods A total of 160 patients with DPN admitted to our hospital were selected and divided into two groups and each for 80 cases, patients in control group were given Neurotropin,and others in observation group were given α-lipoic acid combined with Neurotropin for two weeks. The symptom and nerve conduction velocity were compared before and after treatment of the two groups. Results The EMG showed that motorand sensory nerve conduction velocity of mediannerve cord, nervus peroneus communis, tibial nerve after 2 weeks of the two groups were significant higher than before treatment （P 〈 0.05）, and the conduction velocity of MCV and SCV after treatment in the observation group was better than the control group（P 〈 0.05）. In the observation group, there were 34 cases of excellent, 43 cases of effective, 4 cases of invalid and total efficiency of observation group was 96.25% and higher than control group 66.25% （P 〈 0.01 ）. Conclusion The method of α-lipoic acid combined with Neurotropin is efficiency, reliable and suitable in clinic.