Survivin在多发性骨髓瘤中的表达及其与VEGF的相关性研究

Survivin expression in multiple myeloma and its correlation with VEGF

目的观察Survivin在多发性骨髓瘤中的表达及其与VEGF的相关性。方法选择2011年1月～2012年6月在我院就诊的MM患者40例,所有患者均符合张之南主编的《血液病诊断和疗效标准》(1998年)中提出的MM诊断标准及疗效标准,采用免疫组化S-P法检测多发性骨髓瘤患者Survivin、VEGF的表达以及二者间的相关性。结果 Survivin在MM患者骨髓组织中的阳性率达72.5%(29/40),VEGF在MM患者骨髓组织中的阳性率达65.0%(26/40)。Survivin、VEGF在MM患者骨髓组织中的表达与治疗情况及肿瘤分期关系密切,差异存在显著性(P<0.05)。Survivin与VEGF在MM患者骨髓组织中共同阳性表达例数为23例,共同阴性例数8例,MM患者骨髓组织中Survivin和VEGF表达呈正相关(r=0.562,P<0.05)。结论 Survivin和VEGF均参与了MM的发生、发展过程,且与疾病的进展关系密切,Survivin和VEGF存在协同关系,值得临床予以关注。

Objective To investigate the expression of Survivin in multiple myeloma and its correlation with VEGF. Methods 40 cases of multiple myeloma patients, used immunohistochemical SP assay multiple myeloma tumors of Survivin, VEGF expression, as well as the correlation between VEGF and Survivin. Results Survivin in the bone marrow of patients with MM positive rate was 72.5% （29/40）, the positive rate of VEGF in the bone marrow of patients was 65.0% （26/40）. Survivin, VEGF expression and treatment in the bone marrow of patients with MM and tumor stage were closely related, the difference was significant （P 〈 0.05）. Survivin and VEGF positive expression in the bone marrow of patients with MM the number of cases of 23 cases, the common negative patients ＇in eight cases, MM patients with bone marrow Survivin and VEGF expression was positively correlated （r = 0.562, P 〈 0.05）. Conclusion Survivin and VEGF are involved in the occurrence and development process of the MM, and closely related to the progression of the disease, and the Survivin and VEGF synergistic relationship is worth to be concerned about.