肺炎衣原体与冠心病关系的血清学研究

Serological study of chronic chlamydia pneumoniae infection in coronary artery disease

目的 观察冠心病 (CHD)与慢性肺炎衣原体感染相关的血清学证据。方法 采用Mi cro IF法测定肺炎衣原体 (CP)抗体。结果 发现约 37%CHD患者血清特异性CP IgA抗体水平升高 ,与健康对照组 (4 % )及献血员组 (3 % )差异非常显著 (P <0 0 1) ;特异性CP IgG、CP IgM抗体阳性率与健康对照组及献血员组无显著差异 (P >0 0 5 )。结论 提示CHD患者血清特异性CP IgA抗体升高与慢性CP携带状态有关 ,特异性CP IgA抗体是慢性CP感染的标记物 ,可作为慢性CP携带相关的CHD和其它疾病的科研。

Objective To obtain the serological evidence of chronic infection with chlamydia pneumoniae(CP) in coronary heart diseases.Methods Microimmunofluorescence (Micro IF) was used to determine the immunoglobulin (Ig) class specific antibodies to CP in serum.Results It was found that 37% were approximately elevated titers(1 in 32 or over)of serum specific CP IgA antibodies in coronary heart vascular diseases.Both frequencies were significantly higher than in the controls(healthy subjects:4%,donors:3%),but those of serum specific CP IgG and CP IgM antibodies did not have significant difference from those in the controls(healthy subjects and donors).Conclusion The results suggest that an association between chronic CP infection with serum specific CP IgA antibodies and no association with serum specific CP IgG and CP IgM antibodies.Serum specific CP IgA antibodies serve as markers of chronic CP infection,as an index is used in clinical diagnosis and treatment evaluation and scientific research for related deseases with chronic CP infection(carrier),such as coronary heart diseases and other diseases.