乙醇对雄性生殖内分泌系统的损害及其机制

Study on the damage of alcohol to reproductive and endocrinal systems and their mechanisms on males

目的 研究乙醇对雄性生殖内分泌系统损害机制。方法 测定饮酒和酒精中毒者血T、LH、FSH、E2 、LDH、LDH x、G 6 PD水平和乙醇染毒大鼠血和睾丸匀浆T、LH、FSH、MDA、SOD、GSH Px、CAT、—SH水平。结果 3 0 0 0、 40 0 0mg/kg染毒 70天大鼠血T明显下降 ,LH、E2 、FSH升高 ,血和睾丸匀浆MDA明显升高 ,而SOD、GSH Px、—SH明显下降 ,饮酒和酒精中毒者血T明显下降 ,LH、E2 、FSH升高 ,LDHx、G 6 PD下降。结论 乙醇及其代谢产物对机体产生明显的脂质过氧化作用 ,损伤间质细胞、支持细胞、生精细胞生物膜上的受体、酶 ,从而产生损害作用。

Objective To study the damage of alcohol on reproductive & endocrinal systems and their mechanisms on the males Method The levels of testosterone(T),luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E 2),lactic dehydrogenase(LDH),LDHx,glucose-6-phosphate dehydnogenase(G-6-PD)in the blood of alcohol-drinkers and alcoholism patients were measured.Besides,the T,LH,FSH,malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),catabase(CAT),—SH contents in blood and testis hemogenates of alcohol-fed rats were determined.Results Blood T level in the rats given alcohol 3 000 and 4 000 mg/kg for 70 days were obviously decreased while the LH,E 2,FSH contents in blood increased.MDA in blood and testis hemogenates went up but the SOD,GSH-Px,—SH levels dropped.Blood T level of drinking alcohol for long time and alcoholic poisoning persons were also decreased and the LH,E 2,FSH level in blood went up too.At the same time,LDHx,G-6-PD activity was weakened.Conclusion Alcohol and its metabolites might induce lipid peroxidation in living body,which then could damage the biomembrane,acceptor and enzymes of Leydigs cells,supportive cells and spermatogenic cells.