摘要
目的 :探讨充血性心力衰竭时内皮素 - 1(ET- 1)和一氧化氮 (NO)的变化及氯沙坦 (losartan)对其的影响。 方法 :充血性心力衰竭患者 6 0例 ,随机分为氯沙坦组和依那普利 (enalapril)组 ,疗程 12周。测定治疗前、治疗 1、12周血浆血管紧张素 (Ang )、ET- 1及 NO变化。 30例健康体检者作为对照组。 结果 :充血性心力衰竭患者血浆 Ang 、ET- 1及 NO水平升高 (P<0 .0 1) ,NO/ ET- 1值降低 (P<0 .0 5 )。氯沙坦治疗后血浆 ET- 1及 NO水平降低 (P<0 .0 1) ,NO/ ET- 1值升高 (P<0 .0 5 )。 结论 :充血性心力衰竭患者血浆 ET- 1、NO水平升高是心力衰竭病理生理特征之一。氯沙坦治疗后可获得有益的临床及神经激素效应 ,且有较好的耐受性。
Objective:To study the effects of losartan on plasma endothelin 1 (ET 1) and nitric oxide (NO) levels in patients with congestive heart failure (CHF). Methods:Sixty patients with CHF were randomised group for either to losartan or to enalapril.Plasma angiotensin Ⅱ(AngⅡ) and ET 1 concentrations were assessed by radioimmunnoassay,and NO concentrations were assessed by methods of nitric acid reductase. Results:Plasma ET 1、NO and AngⅡ levels were higher in patients with CHF than those in normal subjects (p<0 01).NO/ET 1 ratio was decreased in CHF (p<0 05).Plasma ET 1 and NO levels was reduced,thus,NO/ET 1 ratio was increased after 1 week and 12 weeks of therapy in two groups (p<0 05). Conclusion:CHF is characterized by increase of plasma ET 1 and NO levels.This study showed that oral losartan administered to patients with CHF resulted in beneficial clinical and neurohormonal effects,with rather good tolerability.
出处
《中国循环杂志》
CSCD
北大核心
2000年第5期287-288,共2页
Chinese Circulation Journal
