甘肃省六地市先天性心脏病流行病学调查研究

The Epidemiological Investigation of Congenital Heart Disease in Gansu Province

目的 :对地处三大高原交汇地带的甘肃省黄河流域和河西走廊的儿童、青少年进行先天性心脏病 (先心病 )流行病学调查及遗传学研究。 方法 :省先心病调查专题组调查了甘肃省三市 (兰州市、白银市、张掖市 )、三地区 (定西地区、酒泉地区、金昌地区 ) 2～ 19岁儿童、青少年共 115 5 35名 ,普查率为 96 .2 %。 结果 :查出先心病患者 6 6 0例。总患病率为 5 .71‰。其中 2～ 5岁者患病率显著高于 6～ 19岁者 (P<0 .0 1) ;筛查出36个高发家系 ,家族患病率为 142 .40‰。 结论 :河西走廊先心病发病率高于黄河流域。高原地区先心病患儿在学龄前形成重度肺动脉高压而夭折率偏高。

Objective:To carry out epidemiological investigation to children and adolescent with congenital heart diseases (CHD)and research of genetics. Methods:The CHD investigation team examined 115 535 children and adolescent of 2～19 years old in 3 cities (Lanzhou city,baiyin city,zhangye city) and in 3 region (dingxi,jiuquan,jinchang) in Gansu Province.The rate of general investigation was 96 2%. Result:Six hundrend and sixty patients with CHD was filtrated.The total sickening rate is 5 71‰.The sickening rate of 2～5 years group is higher than the rate of 6～19 years group remarkably.Thirty six highly attacked families was fished out.The family sickening rate is 142 40‰. Conclusion:The incidence and sickening rate of Gansu Western Corridor area is higher than one of Yellow River field.The children with CHD in plateau region become severe pulmonary arteries pressure in preschool age and have high rate of die young.