轻症室间隔缺损病人心肌成熟时限的研究

Mature time demarcation of human immature myocardium

目的 研究人未成熟心肌的成熟时限。方法 以不同年龄层次无明显症状的轻症室间隔缺损 (室缺 ) 4 8例病人心肌为研究对象 ,按年龄分为 6组 ,每组 8例。从形态、物质代谢 (钙、能量 )、氧自由基代谢、含水量、酶活性等方面进行观察。结果 随着年龄的增长 ,轻症室缺患儿未成熟心肌细胞直径、心肌细胞肌原纤维体密度、心肌细胞线粒体密度与年龄呈显著的正相关 ;心肌超氧化物歧化酶 (SOD)活性、心肌ATP及糖原含量与年龄呈负相关 ;心肌丙二醛 (MDA)含量、心肌肌浆网Ca2 + ATPase活性及其Ca2 +含量与年龄呈显著性正相关 ,其各指标成熟时间先后不一 ,约在 6～ 9岁左右多数指标基本成熟。结论 轻症室间隔缺损病儿未成熟心肌结构、功能、代谢约在 9岁左右基本成熟。

Objective To study the mature time demarcation of human immature myocardium. Methods The morpho ultrastructure, calcium metabolism, energy metabolism and oxygen free radicals metabolism of myocardium of children with ventricular septal defect without pulmonary hypertention or any clinical symptoms were studied at different ages. Results The immature myocardium possessed its own structure and functional characteristics. Before viripotent period, the age related myocardial changes developed progressively to mature and almost approached to mature levels at 6～9 years old. The indices of immature myocardium developing to mature levels were inconsistent. Conclusion The structure and function of human immature myocardium approaches to mature levels at 6～9 years old.