b-FGF在肾癌组织中表达的临床意义

Expression of b FGF in renal cell carcinoma

目的 探讨b FGF(碱性成纤维细胞生长因子 )在肾癌中表达的临床意义。 方法 采用斑点杂交技术和免疫组化技术测定 2 0例肾癌患者癌组织、癌旁和正常肾组织b FGF表达情况。 结果 肾癌组织中b FGF表达明显高于癌旁和周围正常肾组织 (P <0 .0 1)。b FGF表达升高与肿瘤分期、分级密切相关 ,与肿瘤大小无明显关系。 结论 b FGF为肾癌组织自身分泌 。

Objective To investigate the clinical significance of b FGF in human renal carcinoma. Methods 20 cases of renal carcinoma were examined using RNA dot blot hybridization and immunohistochemical technique. Results b FGF expression was significantly higher in human renal cancer tissue than the normal human renal tissue and tissue surrounding the tumor. b FGF expression was of no statistic significance as to tumor size, but it was of statistic significance as to clinical stage or clinical grade. Conclusions b FGF is secreted from tumor tissue itself. b FGF is closely involved in the development and growth of renal cell carcinoma.