妊娠梅毒患者外周血T淋巴细胞亚群的检测及临床意义

Determination of peripheral blood T-lymphocyte subgroup in syphilitic Patients with pregnancy and its clinical significance

目的了解妊娠梅毒患者的细胞免疫功能状态,研究进入血液后的梅毒螺旋体对机体外周血中各淋巴细胞亚群的影响情况。方法应用流式细胞仪检测了9例活动期妊娠梅毒患者及18例恢复期妊娠梅毒患者外周血的CD3+、CD4+、CD8+及CD4+/CD8+比值。并以20例正常孕妇作为对照。结果活动期妊娠梅毒患者外周血CD4+及CD4+/CD8+比值明显低于正常对照组,而CD8+则显著高于正常人对照组(P<0.01)。恢复期妊娠梅毒患者CD4+、CD4+/CD8+比值回升接近正常,而CD8+也回落接近正常。结论本研究结果提示活动期妊娠梅毒患者存在细胞免疫功能抑制现象。

Objective To understand the cellular immunity function in syphilitic patients with pregnancy, and determine the effect of TP（ Treponema pallidum） infection on various lymphocyte subpopulations in the peripheral blood of the patients. Methods T - lymphocyte subpopulation in the peripheral blood of 9 patients in active phase of the disease and 18 patients in recovery phase of the disease were detected by flow cytometry. Twenty healthy people were recruited as control. Results The number of CIM ＋ and CD4 ~/CD8 ＋ ratio in active phase of the disease were significantly lower and the number of CD8 ＋ was remarkably higher as compared with those in the control group （ P 〈 0. 01 ） ; The number of CDd- ＋ and CD4 ＋/CD8 ＋ ratio in recovery phase of the disease rose to and the number of CD8 ＋ fell to the level of the control group. Conclusions This study shows that cellular immunity in active phase of the disease is prominently suppressed.