传统抗癫痫药物与新型抗癫痫药物对认知功能的影响

Influence of traditional antiepileptic drugs and new antiepileptic drugs on cognitive function

目的评价传统抗癫痫药物代表丙戊酸钠与新型抗癫痫药物代表对癫痫患者认知功能的影响。方法将80例癫痫患者随机分为丙戊酸钠组与拉莫三嗪组,利用韦氏智能测定,分别于治疗前及用药6个月后对患者认知功能进行统计分析。结果两组癫痫患者用药前语言智商(VIQ)操作智商(PIQ)总智商(FIQ)分值无明显差异;在用药6个月,丙戊酸钠组,语言智商(VIQ)操作智商(PIQ)总智商(FIQ)分值明显下降,而拉莫三嗪无明显变化,两组结果具有统计学意义(P<0.05)。结论丙戊酸钠对患者认知功能有影响,而拉莫三嗪对患者认知功能无明显影响。

Objective To evaluate the effects of traditional antiepileptic drugs sodium valproate and new antiepileptic drugs lamotrigine in epileptic patients IQ. Methods A total of 80 epileptic patients were randomly assigned to receive sodium valproate group or lamotrigine group. To test the cognitive function, neuropsychological evaluation was performed before treatment, at an 6 months after medication using Webster ＂s intelligent determination. Results Before treatment, epilepsy patients using lamotrigine compared with valproate had no significant difference in verbal IQ （VIQ） operate IQ （PIQ） IQ （FIQ） score, after six months, compared with before treatment, verbal IQ （VIQ） operation IQ （PIQ） IQ （FIQ） score decreased in valproate, but not lamotrigine. Conclusions Valproatr can cause cognitive function disorder in epileptic patients. There is no significant difference of lamotrigine on cognitive function in natients with epilensv.