非小细胞肺癌中E-cadherin表达及与临床病理因素的关系

A Study of E Cadherin Expression and Its Relation with Clinical Pathological Factors in Non small Cell Lung Cancer

目的 :研究上皮钙粘素 (E- cadherin,E- cad)在非小细胞肺癌中的表达 ,探讨 E- cad表达与组织类型、细胞分化程度、淋巴结转移及预后的关系。方法 :采用 S- P免疫组化方法 ,检测 6 5例非小细胞肺癌中 E- cad的表达情况。结果 :6 5例非小细胞肺癌中 E- cad的异常表达率为 86 .2 % ,其表达与组织学类型间无关 (P >0 .0 5 ) ,与分化程度、淋巴结转移、术后生存时间显著相关 (P <0 .0 5 ) ,并与非小细胞肺癌患者的预后显著相关 (P <0 .0 5 )。结论 :E- cad表达异常可能与非小细胞肺癌的恶变过程有关 ,可作为判断非小细胞肺癌恶性程度及预后的指标。

Objective:Our purpose was to investigate the clinical significance of E cadherin (E cad) in non-small cell lung cancer(NSCLC). Methods:Immunohistochemical method, S P method, was adopted to detect the expression of E cad proteins in 65 NSCLC patients. Results:The abnormal expression rate of E cad in NSCLC were 86.2%. Its expression was not related to the histological type (P>0.05). The expression of E cad was related to differentiation, lymphatic metastasis, and survival time(P<0.05). The lever of E cad expression in primary tumors was statistically significant prognostic factor (P<0.05). Reduced E cad expression in NSCLC was associated with unfavorable prognosis. Conclusion:Aberrant expression of E cad played an important role in the malignant progression of NSCLC, and could be used as maker of malignant potential and prognosis factor of NSCLC.