大肠埃希菌临床分布及耐药性分析

Clinical distribution and drug resistance analysis of Escherichia coli

目的了解医院大肠埃希菌的临床分布及耐药性,为临床用药提供依据。方法收集医院2011年1月～2012年6月常规培养检出的396株非重复的大肠埃希菌,分析其在各种临床标本中的分布特征、耐药状况。结果大肠埃希菌从临床标本中以痰液和脓液标本的检出最常见,分别占24.24%和23.49%,其余依次是尿液、其他分泌物、血液、引流液、其他标本、胆汁,分别占20.20%、18.18%、6.06%、5.30%、1.52%、1.01%;大肠埃希菌对氨苄西林、复方新诺明、环丙沙星、左氧氟沙星有较高的耐药性,耐药率均>60%,对亚胺培南、美洛培南、阿米卡星较敏感。结论大肠埃希菌存在比较严重的耐药性,临床应尽早进行细菌培养和对抗菌药物的耐药性监测,以指导临床合理用药。

Objective To investigate the distributionanddrug resistance of Escherichia coli isolates and to provide basis for clinical applicationof antibiotics. Methods The data on 396 strains of Escherichia coli by cultured in normal methods from Jan 2011 to Jun 2012 were collected to analyze the changes in Clinical specimens and ward distribution and drug resistance. Results Of totally 396 strains of Escherichia coli isolated, the specimens were mainly obtained from sputum and pus, accounting for 24.24% and 23.49% ,the next ,in turn are urine, other secretions, blood, fluid drainage, other specimens, bile, accounting for 20.20%, 18.18% ,6.06 %,5.30%, 1.52%, 1.01% ; Escherichia coli to Ampicillin, Cotrimoxazole, Ciprofloxacin, Levofloxacin has higher resistance, resistance rate was 〉60% ,to Imipenem, Meropenem, Amikacin sensitive. Conclusion Escherichia coil exist more serious resistance, clinical early bacterial culture and antibiotic resistance of monitoring, to guide clinical rational drug use.