大黄联合血液净化治疗鱼胆中毒并发多脏器功能障碍综合征

Retrospective Analysis of Rhubard Combined with Blood Purification in the Treatment of Fish Bile Poisoning with Multiple Organ Dysfunction Syndrome

目的:评价大黄联合血液净化治疗鱼胆中毒并发多脏器功能障碍综合征的临床疗效和安全性。方法:采用回顾性分析方法,37例血液净化治疗鱼胆中毒患者为对照组,32例大黄联合血液净化治疗鱼胆中毒患者为治疗组,比较2组受损脏器恢复情况、治愈率、病死率及药品不良反应等。结果:2组患者治疗后21d血尿素氮、血肌酐、N-乙酰β-D氨基葡萄糖苷酶、尿量恢复率、ALT、AST、总胆红素、直接胆红素,少尿期恢复时间、消化系统损伤恢复倒数,凝血酶原时间、血小板(第7天),痊愈时间、治愈率等指标比较,差异均有统计学意义(P<0.05)。结论:大黄联合血液净化治疗鱼胆中毒并发多脏器功能障碍综合征疗效优于单纯血液净化治疗。

Objective：To evaluate the clinical curative effect and safety of rhubarb combined with blood purification in the treatment of fish bile poisoning with multiple organ dysfunction syndrome（MODS）.Method：In the study group,32 patients with fish bile poisoning were treated with rhubarb and blood purification during November 2007 to February 2012.In the control group,37 patients with fish bile poisoning were treated with blood purification during January 1993 to October 2007.The recovery of impaired organs, curative rate,case fatality rate and adverse effects were compared between the two groups.Result：After the treatment,there were significantly statistical differences in the recovery of BUN,Scr,urinary volume recovery rate,NAG,ALT,AST,TBIL,DBIL,length of oliguria stage,digestive system injury,PT,PLT,healing time,curative rate and case fatality rate in the study group compared with those in the control group（P 0.05）.Conclusion：Rliubarb combined with blood purification in the treatment of fish bile poisoning with MODS is better than blood purification alone.