苦参碱氯化钠注射液与甘草酸二铵治疗急性白血病化疗后肝损伤的疗效观察

The Efficacy Observation of Matrine Sodium Chloride Injection and Glycyrrhizic Acid Diamine for the Treatment of Acute Leukemia Chemotherapy after Liver Injury

目的:评价苦参碱氯化钠注射液(恒迈)与甘草酸二铵治疗急性白血病化疗后肝损伤的疗效。方法:46例化疗所致轻度肝损伤的急性白血病患者随机分成两组。26例为治疗组,20例为对照组,两组均给予甘草酸二铵治疗。治疗组加用苦参碱氯化钠注射液(恒迈)治疗。观察两组治疗前后ALT、GGT、胆红素的变化及疗效差别。结果:治疗后治疗组的ALT显著低于治疗前,其疗效和肝脏功能改善均优于对照组,差异有统计学意义(P<0.05)。结论:苦参碱氯化钠注射液与甘草酸二铵治疗化疗所致肝损伤均有效,而苦参碱氯化钠注射液联合甘草酸二铵起效更快、疗程更短,且降低胆红素效果更为明显,值得临床上推广应用。

Objective：To evaluate the Matrine Sodium Chloride Injection（constant step） with the of glycyrrhizic acid diamine treatment of acute leukemia chemotherapy efficacy of liver injury.Methods：46 cases of acute leukemia patients with chemotherapyinduced mild liver injury were randomly divided into two groups.26 cases of treatment group,20 patients of the control group,two groups were given the treatment of glycyrrhizic acid diamine.Treatment group Matrine Sodium Chloride Injection（constant step） treatment.Observed before and after treatment ALT,GGT,bilirubin changes and efficacy difference.Results：After treatment,the ALT treatment group was significantly lower than before treatment,its efficacy and improved liver function than the control group,the difference was statistically significant（P0.05）.Conclusion：Matrine Sodium Chloride Injection glycyrrhizic acid diamine treatment of chemotherapy-induced liver injury are effective Matrine Sodium Chloride Injection combined with the glycyrrhizic acid diamine faster onset,shorter course of treatment,and reduce bile red the prime effect becomes more apparent,worthy of clinical application.