联合应用卡培他滨与放射治疗对40例老年人进展期胃底贲门癌的效果观察

Clinical Observation of Capecitabine Combined with Radiotherapy in 40 Elderly Patients with Advanced Cancer of Cardiac and Stomach Fundus

目的:探讨卡培他滨联合放射治疗(放疗)在老年进展期胃底贲门癌治疗中的临床效果。方法:选择80例进展期胃底贲门癌老年患者,随机分为观察组与对照组,每组40例,观察组给予卡培他滨联合3D-CRT放疗治疗,对照组给予3D-CRT放疗,对比两组患者疗效与不良反应。结果:观察组总有效率为90.0%(36/40),显著高于对照组的67.5%(27/40)(P<0.05);随访中观察组死亡13例(32.5%),显著少于对照组的22例(55.0%)(P<0.05),观察组平均存活时间(3.4±1.1)年,显著长于对照组的(2.6±1.2)年(P<0.01);两组不良反应发生率比较无显著差异(P>0.05)。结论:卡培他滨联合3D-CRT放疗对于老年进展期胃底贲门癌患者具有较好的疗效,同时并不增加不良反应与副作用的发生率,值得临床推广。

Objective：To discuss the clinical effects of capecitabine combined with radiotherapy in patients with advanced cancer of cardiac and stomach fundus.Methods：80 elderly patients with advanced cancer of cardiac and stomach fundus were devided into the observation group（n=40） and the control group（n=40） randomly.Results：The total effective rate in the observation group was 90.0%（36/40）,significantly higher than 67.5%（27/40） in the control group（P0.05）;there were 13 patients（32.5%） died in the observation group during follow-up,significantly lower than 22（55.0%） in the control group（P0.05）;The mean survival time in the observation group was（3.4±1.1） years,significantly higher than（2.6±1.2） years in the control group（P0.01）;but no significantly difference in the incidence of adverse reactions（P0.05）.Conclusion：Capecitabine combined with radiotherapy is effective in patients with advanced cancer of cardiac and stomach fundus,and does not increase the incidence of adverse reactions and side effects,it＇s worthy of promotion in clinical.