E-cadherin和CD44V6对乳癌腋窝淋巴结转移的预测价值

Prediction value of E-cadherin and CD44V6 for axillary lymph node metastasis of breast cancer

目的:探讨用乳癌组织中E-cadherin和CD44V6的表达水平预测乳癌腋窝淋巴结转移的价值。方法:用免疫组化法检测98例乳癌(浸润性导管癌)患者手术切除标本中E-cadherin和CD44V6的表达情况,以术后病理检查结果为金标准,根据E-cadherin和CD44V6的表达水平预测腋窝淋巴结转移情况,分析单一因素和联合模式预测的灵敏度、特异度、误诊率和漏诊率等指标。结果:E-cadherin单一因素预测腋窝淋巴结转移的灵敏度为60.71%,漏诊率为39.29%,特异度为92.86%,误诊率为7.14%;CD44V6单一因素预测腋窝淋巴结转移的灵敏度为64.29%,漏诊率为35.71%,特异度为61.91%,误诊率为38.10%;E-cadherin和CD44V6串联模式预测的灵敏度为41.07%,漏诊率为58.93%,特异度为95.24%,误诊率为4.76%;E-cadherin和CD44V6并联模式预测的灵敏度为83.93%,漏诊率为16.07%,特异度为59.52%,误诊率为40.48%。结论:E-cadherin单一因素和E-cadherin与CD44V6串联模式预测乳癌淋巴结转移的特异度高,可为腋窝淋巴结清扫术的取舍和术后治疗方案的选择提供帮助;E-cadherin与CD44V6并联能提高淋巴结转移的检出率。

Aim：To analyze the value of the expressions of E-cadherin and CD44V6 in carcinoma tissue for evaluating axillary lymph node metastasis of breast cancer.Methods：The expressions of E-cadherin and CD44V6 in carcinoma tissue of 98 cases of primary invasive ductal carcinoma were detected by immunohistochemistry.The sensitivity,specificity,misdiagnosis and false negative rate compared with the pathology results were calculated.Results：Based on the results of pathology,for the evaluation of axillary lymph node metastasis,the sensitivity of E-cadherin was 60.71%,the false negative rate was 39.29%,the specificity was 92.86% and the false positive rate was 7.14%;the sensitivity of CD44V6 was 64.29%,the false negative rate was 35.71%,the specificity was 61.91%,and the false positive rate was 38.10%.In the series model of E-cadherin and CD44V6,the sensitivity was 41.07%,the false negative rate was 58.93%,the specificity was 95.24%,and the false positive rate was 4.76%.In the parallel model of E-cadherin and CD44V6,the sensitivity was 83.93%,the false negative rate was 16.07%,the specificity was 59.52% and the false positive rate was 40.48%.Conclusion：The single factor of E-cadherin and the series model of E-cadherin and CD44V6 have high specificity,and could provide help for the choose of axillary lymph node dissection and the treatment programs after surgery.The parallel model of E-cadherin and CD44V6 could increase the detection rate of lymph node metastasis.