尿总蛋白肌酐比（TPCR）与胱抑素C-在糖尿病中的应用

An Application of Urinary Protein/Creatinine Ratio（TPCR） and Cystatin-C in Diabetic

目的 探讨尿总蛋白肌酐比（TPCR）与胱抑素C（CysC）等的关系及对糖尿病的临床意义.方法 采用免疫比浊法测定67例糖尿病患者的血清CysC,用苦味酸法测定血清、尿肌酐（cr）,邻苯三酚红比色测定法测定尿总蛋白,同时计算出尿总蛋白肌酐比（TPCR）.结果 糖尿病患者按照尿总蛋白（TPCR）分两组：TPCR≥200 mg/gCr组和TPCR＜200 mg/gCr组,两组血清CysC,TPCR分别是1.24±0.64 mg/L,1 869.67±2 207.58 mg/L和0.957 5±0.51 mg/L,64.68±46.55 mg/L.CysC与TPCR呈显著正相关（r=0.9128,P〈0.05）,差异有统计学显著性意义.结论 以TPCR 200 mg/gCr分组或为划界值是判别糖尿病病人早期肾损害程度最良好的指标.

Objective To investigate a relation between the urinary protein/creatinine ratio（TPCR） and cystatin-C,clinical significance for diabetes. Methods Determined serum cystatin-C by immunoturbidimetry for 67 diabetic;determined creatinine by 2,4,6-trinitrophenol methods and determined urinary protein by Pyrogallol red-molybdate complex method. Simultaneously calculated urinary protein/creatinine ratio（TPCR）. Results Diabetic subgroup according to urinary protein/creatinine ration （TPCR）,in ≥200 mg/gCr,〈200 mg/gCr two subgroup, serum cystatin-C and TPCR respectively was 0.24± 0.64 mg/L,1 869.67±2 207.58mg/gCr and 0. 957 5±0.51 mg/L,64.68±46.55 mg/gCr. Serum cystatin-C and TPCR to offer predominance positive correlation （r=0. 912 8, P〈0.05）. Conclusion It is most favourable indicatrix to distinguish morning renal injury in diabetic with diabetic subgroup according to urinary protein/ereatinine ratio（TPCR） 200 mg/gCr, probably demarcate according to TPCR 200 mg/gCr.