网织血小板检测在妊高征患者中的临床意义

Clinical Significance of Detecting Reticulated Platelet in Pregnancy-Induced Hypertension （PIH）

目的 探讨网织血小板在妊娠高血压综合征（简称妊高征）患者中的变化及临床意义.方法 对经临床确诊的108例妊高征患者、40例正常晚期妊娠妇女与40例正常非孕妇女进行网织血小板百分率（IPF%）、血小板计数（PLT）、平均血小板体积（MPV）及血小板分布宽度（PDW）的检测,并进行统计学分析.结果 妊高征组的IPF%较正常非孕对照组及正常晚期妊娠组明显升高,与正常非孕对照组比较差异有统计学意义（t=3.94,P〈0.001）,与正常晚期妊娠组比较差异有统计学意义（t=3.30,P=0.001）.妊高征组的PLT较正常非孕对照组及正常晚期妊娠组降低,与正常非孕对照组比较差异有统计学意义（t= 2.02,P=0.042）,而与正常晚期妊娠组比较差异无统计学意义（t=0.30,P=0.785）.妊高征组的MPV较正常非孕对照组及正常晚期妊娠组升高,与正常非孕对照组比较差异有统计学意义（t=3.73,P〈0.001）,而与正常晚期妊娠组比较差异无统计学意义（t=1.41,P=0.146）.妊高征组的PDW较正常非孕对照组及正常晚期妊娠组明显升高,与正常非孕对照组比较差异有统计学意义（t=4.28,P〈0.001）,与正常晚期妊娠组比较差异有统计学意义（t=3.38,P=0.001）.结论 网织血小板检测能够更准确地反映骨髓中血小板的生成情况,对监测妊高征病情发展及预测预后有一定的临床价值.

Objective To investigate the change of the reticulated platelet in pregnancy-induced hypertension （PIH）. Methods 108 PIH women,40 normal late pregnant women and 40 normal un-pregnant women were studied. IPF% ,PLT,MPV and PDW were measured. Results IPF% and PDW were higher in PIH women than those in normal un-pregnant women （t= 3.94,P〈0. 001;t=4. 28,P〈0. 001） and normal late pregnant women （t=3.30,P〈0. 001;t=3.38,P=0. 001）. PLT was lower in PIH women than those in normal un-pregnant women （t= 2.02 ,P〈0. 042） ,hut there was no significant difference compared to normal late pregnant women （t=0.30,P〈0. 785）. MPV was higher in PIH women than those in normal unpregnant women （t= 3.73 ,P〈0. 001） ,but there was no significant difference compared to normal late pregnant women （t= 1.41,P〈0. 146）. Conclusion The detection of reticulated platelet couldreveal platelet production in bone marrow,which have a certain clinical value on the development and prognosis of PIH.