台山市艾滋病免费抗病毒治疗疗效分析

Analysis of the efficacy of free antiviral treatment among HIV/AIDS patients in Taishan City

目的探讨台山市艾滋病抗病毒治疗的效果,为进一步开展有效的抗病毒治疗工作提供依据。方法收集2005-2011年台山抗病毒治疗患者的相关资料,统计分析患者基本情况、治疗方案、治疗前后CD4+T淋巴细胞计数、病毒载量、临床症状体征、终止治疗情况以及生存状况的变化。结果 139例病人,静脉吸毒感染占66.91%,男性71.94%,已婚或同居62.59%,年龄25～55岁的占92.80%。病人CD4+T淋巴细胞计数治疗1年后与治疗前基线相比,平均增长204.02/mm3;治疗后86.67%病人病毒载量<40拷贝/mL;各种机会感染症状体征发生率由治疗前的58.06%下降到治疗后1年的3.22%;55.39%的病人出现各种药物不良反应;停药病人占12.95%,死亡病例占7.19%,失访病例占11.51%;病人生存率提高,维持治疗3年生存率达到80.00%。结论抗病毒治疗效果显著,服药依从性直接关系到治疗效果。

Objective To explore the efficacy of antiviral treatment in HIV/AIDS patients and provide scientificbasis for further effective therapy. Methods Relevant information on the antiviral treatment in HIV/AIDS patients from 2005 to 2011 in Taishan was collected. The basic information of patients, their treatment regimes, CD4^＋ T cell counts before and after treatment, viral load, clinical symptoms and signs, termination of treatment and changes of living conditions were statistically analyzed. Results Of the 139 patients, 66.91% were infected via intravenous drug use,71.94% were male, 62. 59% were married or cohabiting, 92.80% were aged from 25 to 55 years. After antiviral treatment for one year, the CD＋ T lymphocyte counts were increased by 204.02/mm3 compared to the baseline before treatment; the viral load in 86.67% patients after the treatment was〈40 copy/mL; the incidence of various opportunistic infections with clinical symptoms and signs was decreased from 58.06% to 3.22% after one year treatment; various drug adverse reactions appeared in 55.39 ~ patients. The patients who withdrew from treatment accounted for 12.95%. The deaths accounted for 7.19%, and the lost cases accounted for 11.51%. The survival rate of patients treated for three years was increased to 80.0%. Conclusion Significant results are obtained in antiviral therapy, compliance seemes to have direct association with the efficacy of the treatment.