山东省HIV与HCV共感染者的流行病学分析

Epidemiological analysis of HIV and HCV co-infection in Shandong

目的了解丙型肝炎病毒(HCV)在山东省艾滋病病毒(HIV)感染者中的感染状况,分析HIV、HCV共感染者的流行病学特征。方法对2000-2010年底,山东省报告的HIV感染者/艾滋病(AIDS)病人确证时的血样进行HCV检测,选取现在存活的、年龄≥18岁的HIV感染者和AIDS病人为研究对象,通过研究对象HIV确证后的首次随访调查表,收集流行病学信息,进行单因素分析和多因素Logistic回归分析。结果 HIV与HCV共感染率为41.7%(842/2 021)。单因素分析发现,不同文化程度、不同性别、籍贯和传染途径、不同民族之间差异有统计学意义(P<0.05),在此基础上进行多因素的Logistic回归分析发现,性别、籍贯和感染途径是HIV/HCV共感染的独立危险因子。结论不同性别、籍贯和传染途径中HIV、HCV共感染率不同,应引起重视。

Objective To understand the HCV infection status among HIV infected individuals in ShandongProvince, and analyze the epidemiological characteristics of HIV/HCV co-infection. Method The confirmatory blood samples from HIV positive cases reported in Shandong Province from 2000 to 2010 were taken for HCV tests, and the survived HIV positive cases aged above 18 years were selected as the study subjects. Epidemiological information was obtained at the first follow up to those who were confirmed as HIV positive and was subject to one-way ANOVA and multivariate logistic regression analysis. Results The HIV/HCV co-infection rate among the subjects accounted for 41.7%（842/2 021）. The single factor analysis showed that there was a significant difference among the subjects with different educational backgrounds, genders, household registers, routes of transmission, date of confirmation and ethnic （P〈0.05）. Furthermore, multivariate logistic repression analysis showed that gender, native places and route of transmission were associated with HIV/HCV co-infection. Conclusion The HIV/HCV coinfection rate is distinct among subjects with different genders, native places and the routes of transmission, to which closer attention should be paid.