深圳市男男性行为人群HIV/梅毒发病密度研究

Incidence density of HIV/syphilis among men who have sex with men in Shenzhen

目的了解深圳市男男性行为人群(MSM)的艾滋病病毒(HIV)/梅毒发病密度,探索防治性病对预防控制艾滋病的作用。方法知情同意原则下,招募符合纳入标准的MSM;建立并保持队列,收集社会人口学、性行为和安全套使用等资料;抽血检测HIV/梅毒,随访观察HIV/梅毒转归结局。结果 609例入选队列,HIV阴转阳19例,观察总人年数249.7人年,发病密度7.6[95%可信区间(CI):4.6～11.9]/100人年;梅毒酶联免疫吸附试验(ELISA)阴转阳18例,观察总人年数134.9人年,发病密度13.3(95%CI:7.9～21.1)/100人年;梅毒ELISA阳性队列HIV发病密度是梅毒ELISA阴性队列HIV发病密度的2.2倍。结论梅毒对HIV传播具有协同作用,有必要在该人群中实施有效的性病预防措施以控制HIV传播。

Objetive To investigate the incidence density of human immunodeficiency virus（HIV）/syphilis among men who have sex with men （MSM） in Shenzhen and explore the role of sexually transmitted diseases（STD） control in AIDS prevention and control. Method With informed consent, MSM meeting the inclusion criteria were recruited. A cohort was established and maintained. Data concerning socio-demographic information, sexual behavior and condom use were collected. Blood specimens were tested for HIV/syphilis infections and the prognosis was observed through following up. Results A total of 609 MSM were enrolled in the cohort study. Nineteen MSM had HIV sero-conversions. Under the observation for over 249.7 person-years, HIV incidence density was 7.6 per 100 person-years [95% confidence interval（CI）：4.6 to 11.9]. Eighteen MSM had syphilis ELISA sero-conversions and under the observation for over 134.9 person-years, syphilis incidence density was 13.3 per 100 person-years （95% CI：7.9 to 21.1）. HIV incidence density in the syphilis ELISA positive cohort was 2.2 times as high as that in the syphilis ELISA negative cohort. Conclusion Syphilis can increase the risk of HIV acquisition and transmission. It is necessary to carry out effective STD preventive measures for HIV control among MSM.