基于合成高分子的纳米药物载体的研究进展

Research Progress of Polymer-Based Nanoparticle Drug Carriers

基于合成高分子的纳米微粒由于其良好的生物相容性、生物可降解性和粘膜粘附性等特点成为药物载体研究的热点。根据构建纳米药物载体的高分子聚合物结构的差异,将其分为:基于两亲聚合物的纳米微粒(胶团和囊泡)、脂质体、树枝状或超支化大分子、乳液聚合纳米微粒,并对上述纳米微粒作为药物载体在近年来的研究进展进行了归纳和总结,展望了其在药物缓释体系中的广阔应用前景。

Polymer-based nanoparticles have attracted more and more attentions as drug carriers in recent years because of their good biocompatibility, biodegradability and mucoadhesive ability. According to the poly-mer structures,the nanoparticles were divided into four types, including amphiphilic polymer-based nanoparti-cles （micelles and polymersomes）,liposomes, dendrimers and nanoparticles prepared by emulsion polymeriza-tion. And then the research progress of the application of these polymer-based nanoparticles as drug carriers was summarized. And the broad application prospect of these polymer-based nanoparticle drug carriers in the drug controlled release system was looked forward to.