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钴(Ⅱ)对纤维蛋白原硝化损伤及活性的影响研究 被引量：1

Study on Influence of Co(Ⅱ) on Nitration Damage of Fibrinogen and Its Activity
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摘要 以纤维蛋白原为研究对象,运用紫外分光光度法、三维荧光光谱法、SDS-PAGE和Von-Clauss法研究了Co(Ⅱ)参与过氧亚硝酸根(ONOO-)介导的纤维蛋白原硝化反应过程。结果表明,Co(Ⅱ)对ONOO-硝化损伤纤维蛋白原存在明显的促进作用,并加剧了硝化损伤后纤维蛋白原凝聚活性的下降。 Taking fibrinogen as the object,its nitration reaction process via ONOO^- in the presence of Co （Ⅱ） was investigated through ultraviolet spectrometry,3D-fluoreseence spectrum, SDS-PAGE and Von-Clauss method. The results showed that Co（ Ⅱ） promoted remarkably the fibrinogen nitration damage by ONOO^- , and enhanced the clotting activity decrease of the fibrinogen damaged.
作者 丁杨 罗云敬 史建龙 徐世奎
机构地区 北京工业大学
出处 《化学与生物工程》 CAS 2013年第3期17-20,共4页 Chemistry & Bioengineering
基金 国家自然科学基金资助项目(20875006) 北京市自然科学基金资助项目(2102005) 北京市教委科技面上项目(KM201210005032)
关键词 过氧亚硝酸根 纤维蛋白原 Von-Clauss法 钴(Ⅱ) peroxynitrite （ONOO^-） fibrinogen Von-Clauss method Co（ Ⅱ ）
分类号 O611.62 [理学—无机化学] Q51 [生物学—生物化学]
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参考文献11

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同被引文献15

  • 1李华.血浆纤维蛋白原与急性冠脉综合征的相关性研究[J].医学信息（西安上半月）,2006,19(5):867-868. 被引量：4
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化学与生物工程
2013年 第3期

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