甲亢患者手术前后血清TNF-α和IL-6水平变化的临床观察

Changes of the levels of serum TNF-αand IL-6 before and after operation in patients with hyperthyroidism

目的观察甲亢患者手术治疗前后血清TNF-α和IL-6含量的变化。方法用放射免疫法检测40例甲亢患者手术治疗前后血清TNF-α和IL-6的含量,并与40名正常人对比。结果手术治疗前甲亢患者血清TNF-α和IL-6的含量分别为(324.1±89.4)ng/mL和(201.3±64.0)pg/mL,均显著高于正常人组(216.4±81.5)ng/mL和(142.5±50.1)pg/mL,差异有统计学意义(均P<0.01)。手术治疗3个月后TNF-α和IL-6的含量分别为(224.8±84.7)ng/mL和(149.4±51.6)pg/mL,明显低于手术前(均P<0.05),但与正常人组比较无显著性差异(均P>0.05)。结论甲亢未治患者的TNF-α和IL-6较正常人高,手术可降低TNF-α和IL-6的水平。检测甲亢患者手术治疗前后TNF-α和IL-6含量的变化,对了解患者的病情和预后均具有重要的临床价值。

[ Objective ] To observe the changes of the levels of TNF- α and IL-6 before and after operation in patients with hyperthyroidism. [ Methods ] Serum TNF- α and IL-6 levels were measured with radioimmunoassay before and after operation in 40 patients with hyperthyroidism and 40 normal controls. [ Resluts ] Before operation, serum TNF- α and IL-6 levels were both significantly higher in the hyperthyroidism patients than those in controls（both P〈0.01）.Three months after operation, the serum TNF-α and IL-6 levels in the hyperthyroidism patients were both lower than those in them before operation（both P〈0.05）.While compared with the normal controls, there were no significant difference（both P〉0.05）. [ Conclusion ] TNF- α and IL-6 levels were higher in hyperthyroidism patients without treatment.Operation can decrease the TNF- α and IL-6 levels.Measurment the changes of serum TNF-α and IL-6 levels before and after operation might helo know the patients＇ condition and prognosis of hyperthyroidism.