期刊文献+

曲美他嗪治疗冠心病并胰岛素抵抗的临床疗效 被引量:1

下载PDF
导出
摘要 目的观察评估曲美他嗪对冠心病并胰岛素抵抗患者的临床疗效。方法对50例冠心病(非急性期)并胰岛素抵抗患者(两组患者均伴发高血压)随机分为1、2两组,1组为曲美他嗪+硝苯地平+美托洛尔+磺脲类降糖药治疗组,2组为硝苯地平+美托洛尔+磺脲类对照组,治疗10周,观察两组患者治疗前与治疗后餐前空腹和餐后2h血糖、胰岛素水平,监测血压,并整理对比胰岛素敏感指数。结果治疗组治疗后血压、血糖、胰岛素水平降低,胰岛素敏感指数升高,效果明显优于对照组(P<0.05)。结论对于冠心病伴有糖尿病且胰岛素抵抗的患者,曲美他嗪的治疗效果较传统用药更佳,临床疗效值得肯定。
作者 付丽
机构地区 长沙市第三医院
出处 《中国医学工程》 2013年第2期55-55,57,共2页 China Medical Engineering
  • 相关文献

参考文献7

二级参考文献36

共引文献56

同被引文献33

  • 1Loiacono F,Alberti L,Lauretta L,et al.Metabolic therapy for heart failure[J].Recenti Prog Med,2014,105(7):288-294.
  • 2Szwed H,Sadowski Z,Pachocki R,et al.Proposed antiischemic effects of trimetazidine in coronary diabetic patients.A substudy from TRIMPOL-1[J].Cardiovasc Drugs Ther,1999,13(3):217-222.
  • 3Boucher FR,Hearse DJ,Opie LH.Effects of trimetazidine on ischemic contracture in isolated perfused rat hearts[J].J Cardiovasc Pharmacol,1994,24(1):45-49.
  • 4Sentex E,Sergiel JP,Lucien A,et al.Is the cytoprotective effect of trimetazidine associated with lipid metabolism?[J].Am J Cardiol,1998,82(5):18K-24K.
  • 5Dehina L,Vaillant F,Tabib A,et al.Trimetazidine demonstrated cardioprotective effects through mitochondrial pathway in a model of acute coronary ischemia[J].Naunyn Schmiedebergs Arch Pharmacol,2013,386(3):205-215.
  • 6Stanley WC,Marzilli M.Metabolic therapy in the treatment of ischaemic heart disease:the pharmacology of trimetazidine[J].Fundam Clin Pharmacol,2003,17(2):133-145.
  • 7Morillas Blasco PJ,Hernándiz MA,Azorín VI,et al.Mitochondrial changes induced by trimetazidine in the myocardium[J].Med Sci Monit,2005,11(6):162-167.
  • 8Dedkova EN,Seidlmayer LK,Blatter LA.Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure[J].J Mol Cell Cardiol,2013,59:41-54.
  • 9Kantor PF,Lucien A,Kozak R,et al.The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase[J].Circ Res,2000,86(5):580-588.
  • 10Essick EE,Sam F.Oxidative stress and autophagy in cardiac disease,neurological disorders,aging and cancer[J].Oxid Med Cell Longev,2010,3(3):168-177.

引证文献1

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部